tert-Butyl methyl ether → HCID 58591579, compound

Participants

Reaction Steps

To a suspension of dimethyl-[2-(6-methyl-benzo[b]thiophen-2-yl)-ethyl]-amine (1.05 g, 4.78 mmol) in HOAc (5 mL) at 0° C., bromine was added slowly. The mixture was stirred overnight while it was allowed to slowly reach room temperature. MTBE (6 mL) was added and the solid was filtered, washed with MTBE and dried under vacuum. It was taken up in dichloromethane, washed with sat. NaHCO3 and brine, dried (Na2SO4), filtered and concentrated in vacuo to give 1.1 g of [2-(3-bromo-6-methyl-benzo[b]thiophen-2-yl)-ethyl]-dimethyl-amine (77% yield).

Provenance & Evidence