HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-5-phenylpyrazole → 5-chloro-3-[[(5-phenyl-1H-pyrazol-3-yl)amino]methylidene]-1H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-5-phenylpyrazole | HCID 136655 | — |
| Reactant | HCID 178418806 | HCID 178418806 | — |
| Reactant | HCID 178517101 | HCID 178517101 | — |
| Reactant | HCID 178517165 | HCID 178517165 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-chloro-3-[[(5-phenyl-1H-pyrazol-3-yl)amino]methylidene]-1H-indol-2-one | HCID 178517161 | — |
Reaction Steps
The named compound is prepared by substituting E & Z-3-[(hydroxy)-methylene]-5-chloro-1,3-dihydro-indol-2-one for E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one and 3-amino-5-phenylpyrazole for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-5-chloro-1,3-dihydro-indol-2-one (0.100 gms.) is reacted with 0.1668 gms. of 3-amino-5-phenylpyrazole by refluxing in tetrahydrofuran (2.5 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07393870B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-b02df224ad154953ba55140294801df6 |
| Source note | uspto-grants-2008_07 |