HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-5-methylisoxazole → HCID 178428477, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-5-methylisoxazole | HCID 66172 | — |
| Reactant | HCID 178418806 | HCID 178418806 | — |
| Reactant | HCID 178517101 | HCID 178517101 | — |
| Reactant | (3Z)-6-fluoro-3-(hydroxymethylidene)-1H-indol-2-one | HCID 178517312 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178428477 | HCID 178428477 | — |
Reaction Steps
The named compound is prepared by substituting E & Z-3-[(hydroxy)-methylene]-6-fluoro-1,3-dihydro-indol-2-one for E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one and 5-methyl-isoxazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-6-fluoro-1,3-dihydro-indol-2-one (0.033 gms.) is reacted with 0.040 gms. 5-methyl-isoxazol-3-ylamine by refluxing in tetrahydrofuran (0.88 mL) to afford the named compound in the amount of 0.0147 gms.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07393870B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-aa01a192a4ed4dc180427555372467da |
| Source note | uspto-grants-2008_07 |