反应详情

温度

85 °C

Stir a mixture of SiCl4 (1.7 g, 10 mmol, 2 eq.) and NaN3 (1.95 g, 30 mmol, 6 eq.) in 50 mL of acetonitrile for 2 hours. Add 1.07 g of 2-(4-bromophenyl) acetamide (5 mmol, 1 eq.) and heat to 85° C. for 5 hour. Cool to room temperature and filter off the solid wash the solid with EtOAc. Wash the ester layer with water, saturated aq. sodium chloride, dry over MgSO4 and evaporate the solvent to afford 900 mg title compound (80%). MS (m/e): 237.0.

1. temperatureCool to room temperature
2. filtrationfilter off the solid
3. washwash the solid with EtOAc
4. washWash the ester layer with water, saturated aq. sodium chloride
5. dry with materialdry over MgSO4
6. customevaporate the solvent