反应详情

Add Na2SO4(8.5 mmol) to a solution of 4-Bromo-3-nitro-benzoic acid methyl ester (1.2 mmol) in EtOH (40 mL). Heat the reaction at 70° C. for 30 min and then at room temperature overnight. Add a saturated solution of NaHCO3(pH=11-12) and extract with EtOAc (2×50 mL). Dry over NaSO4, filter and evaporate to dryness to provide 4-Bromo-3-amino-benzoic acid methyl ester.

1. temperatureHeat
2. customthe reaction at 70° C. for 30 min
3. customat room temperature
4. customovernight
5. additionAdd a saturated solution of NaHCO3(pH=11-12)
6. extractionextract with EtOAc (2×50 mL)
7. dry with materialDry over NaSO4
8. filtrationfilter
9. customevaporate to dryness