HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Chloride → 4-Bromo-3-(methanesulfonylamino)-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | Methyl 3-amino-4-bromobenzoate | HCID 3928639 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Bromo-3-(methanesulfonylamino)-benzoic acid methyl ester | HCID 69254444 | — |
Reaction Steps
Add Na2SO4 (0.12 mmol) to a suspension of 4-Bromo-3-amino-benzoic acid methyl ester (0.1 mmol) and Et3N (0.1 mmol) in dichloromethane at 0° C. Stir 4 h at RT. Add a saturated solution of NaCl (15 mL), and extract with dichloromethane (2×50 mL). Dry over NaSO4, filter and evaporate to dryness. Purify the residue utilizing flash chromatography (Silica gel-hexane/EtOAc) to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07393868B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-b097c323dd0c44d9ba4d4ac2d7d18996 |
| Source note | uspto-grants-2008_07 |