HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 4-Bromo-2,6-difluoroanisole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromo-2,6-difluorophenol | HCID 2736292 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-Bromo-2,6-difluoroanisole | HCID 2773287 | — |
Reaction Steps
Add iodomethane (2.0 ml, 32.1 mmol) dropwise to a suspension of 4-bromo-2,6-difluorophenol (5.90 g, 28.2 mmol) and potassium carbonate (4.40 g, 31.8 mmol) in acetone (50 ml) at room temperature while stirring vigorously. Heat the mixture under reflux overnight. Evaporate acetone and add dichloromethane. Filter through silica eluting the product with dichloromethane/EtOAc. Concentrate to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07393868B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-a291ed1aa0994e328206e6d5aeacc4dc |
| Source note | uspto-grants-2008_07 |