Phenylboronic Acid → HCID 69254862, compound

Participants

Reaction Steps

Heat in a sealed tube with stirring propane-2-sulfonic acid [2-(4-bromo-phenyl)-thiophen-3-yl]-amide (0.5 mmol), phenyl boronic acid (0.75 mmol), 2M Na2CO3 water solution (0.2 mL) and Pd(PPh3)4(0.05 mmol) in 4.0 ml of an anhydrous and deoxygenated 2:1 DME/EtOH mixture to 80° C.-100° C. for 24 h. Filter mixture through a small silica pad and elute with EtOAc. Evaporate the filtrate. Purify the product by flash chromatography (Silica gel-hexane/EtOAc) to obtain the title compound. MS (ES−): 356 (M−1).

Provenance & Evidence