Hydrochloric Acid → HCID 136395590, compound

Participants

Reaction Steps

Dissolve 2,2-Dimethyl-propionic acid 3,5-difluoro-4′-[3-(propane-2-sulfonylamino)-pyridin-4-yl]-biphenyl-4-yl ester in THF (9 ml) and ethanol (1 ml). Add NaOH 2N (10 ml) and heat the mixture to 60° C. for 7 h. Evaporate solvents and add HCl 3N to acidify the mixture. Apply the acidic mixture to 2 g SCX cartridge. Elute the SCX cartridge with methanol (×3) to remove non-basic impurities. Elute the product with 2N ammonia in methanol to afford, after evaporation, 55.2 mg of the title compound as a yellow solid (50% yield). MS (ES−): 403.

Provenance & Evidence