Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Silicon tetrachloride | HCID 24816 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | HCID 69253310 | HCID 69253310 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178461069 | HCID 178461069 | — |
Reaction Steps
Add NaN3 (4.5 mmol) and a 1M solution of SiCl4 (1.5 mmol) in DCM to a solution of 2-Cyano-4′-[3-(propane-2-sulfonylamino)-thiophen-2-yl]-biphenyl-4-carboxylic acid amide (1.5 mmol) in acetonitrile (50 mL). Stir 15 h at 70° C. Concentrate to dryness under reduced pressure. Dissolve resultant residue in 20 ml of NH4Cl and extract with DCM and the aqueous with EtOAc. Concentrate all organic layers to dryness. Purify by HPLC to provide the title compound. MS (ES−):449(M−1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07393868B2 |
|---|
| Source dataset | uspto-grants-2008_07 |
|---|
| ORD ID | ord-fb6a6c1d36b64063ac532e5c79be5f6c |
|---|
| Source note | uspto-grants-2008_07 |
|---|
