Dimethylformamide → HCID 69254702, compound

Participants

Reaction Steps

Add oxalyl chloride (0.12 mmol) to a suspension of 2-(Propane-2-sulfonylamino)-4′-[3-(propane-2-sulfonylamino)-thiophen-2-yl]-biphenyl-4-carboxylic acid (0.1 mmol) and DMF (0.05 mmol) in dichloromethane at 0° C. Stir 1 h at RT. Concentrate to dryness under reduced pressure. Dissolve resultant residue in 3 ml CH2Cl2 and add (2.8 mmol) of MeNH2 (2M in THF). Concentrate the reaction to dryness and purify by flash chromatography (Silica gel- eluting with 5%MeOH/CH2Cl2). Concentrate the desired fractions to provide the title compound. MS (ES−): 534(M−1).

Provenance & Evidence