Methylamine → HCID 69253638, compound

Participants

Reaction Conditions

Reaction Steps

Add thionyl chloride (0.2 mmol) to a suspension of 2-Cyano-4′-[3-(propane-2-sulfonylamino)-thiophen-2-yl]-biphenyl-4-carboxylic acid (0.1 mmol) in dichloromethane at RT. Stir mixture for 1 h at 50° C. and concentrate to dryness under reduced pressure. Add to the resultant residue 0.5 mmol MeNH2 (2M in THF). Concentrate the reaction to dryness and purify with flash chromatography (Silica gel-5%MeOH/CH2Cl2). Concentrate the desired fractions to provide the title compound. MS (ES−):438 (M−1).

Provenance & Evidence