Hydrochloric Acid → 4-((5-Bromo-2-chlorophenyl)methyl)phenol

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Reaction Steps

A solution of 14.8 g 4-bromo-1-chloro-2-(4-methoxy-benzyl)-benzene in 150 ml dichloromethane is cooled in the ice bath. Then 50 ml of a 1 M solution of boron tribromide in dichloromethane are added and the solution is stirred for 2 h at ambient temperature. The solution is then cooled again in the ice bath, and saturated potassium carbonate solution is added dropwise. At ambient temperature the mixture is adjusted to a pH of 1 with aqueous 1 M hydrochloric acid, the organic phase is separated off and the aqueous phase is extracted another three times with ethyl acetate. The combined organic phases are dried over sodium sulphate, and the solvent is totally eliminated.

Provenance & Evidence