HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 74696Generated: October 27, 2026
Cesium carbonate → HCID 42613224, compound
https://huagongshe.com/reaction/74696
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Reactant | 7-methoxy-3-(piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-one | HCID 18356852 | — |
| Reactant | (3-Bromo-phenyl)-(5-fluoro-2,3-dihydro-indol-1-yl)-methanone | HCID 58386659 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 42613224 | HCID 42613224 | — |
Reaction Steps
Under an argon atmosphere 7 mg (31 μmol) palladium(II) acetate and 20 mg (32 μmol) BINAP were added to 86 mg (0.31 mmol) 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one, 0.10 g (0.31 mmol) (3-bromo-phenyl)-(5-fluoro-2,3-dihydro-indol-1-yl)-methanone and 0.16 g (0.48 mmol) caesium carbonate in 4.0 mL dioxane, and the mixture was stirred overnight at 120° C. The reaction mixture was then evaporated down and the residue was dissolved in DMF/MeOH and purified by preparative HPLC-MS.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08829006B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-e362fb5fa5d146cbad74cb0a1be41ce0 |
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| Source note | uspto-grants-2014_09 |
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