1,2-Dichloroethane → HCID 59710974, compound

Participants

Reaction Steps

2-[(4′-Trifluoromethyl-biphenyl-2-carbonyl)-amino]-quinoline-6-carboxylic acid, (F-1a2, 0.78 g, 1.79 mM), (S)-2-azido-1-phenyl-ethylamine hydrochloride (0.36 g, 1.79 mM), EDC (0.41 g, 2.15 mM) and HOBT (10 mg, 0.075 mM), were dissolved in CH2Cl2 (15 mL) and treated with triethylamine (0.75 mL, 5.4 mM). The mixture was stirred at room temperature for 16 h, then was diluted with EtOAc (75 mL) and washed with 0.5N HCl (20 mL), aqueous NaHCO3 (20 mL), and brine. The EtOAc fraction was dried (MgSO4), filtered and concentrated. ESMS (m+1) 581; calc. Mw, 580.

Provenance & Evidence