Triphenylphosphine → HCID 69146214, compound

Participants

Reaction Steps

Diethyl azodicarboxylate (1.4 g, 8.1 mmol) was added to a solution of 4-(1,2-dihydroxyethyl)-4-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester (Description 3; 2 g, 6.5 mmol) and triphenylphosphine (2.4 g, 9.1 mmol) in tetrahydrofuran (40 ml). The reaction was stirred at room temperature for 2 hours then the solvent was removed in vacuo. The residue was purified by flash column chromatography on silica, eluting with 1, 2 and 4% methanol/dichloromethane, to give the title compound (1.43 g, 76%).

Provenance & Evidence