Methanol → HCID 69226052, compound

Participants

Reaction Steps

Benzyl 8-hydroxy-6-oxa-2-azaspiro[3.4]octane-2-carboxylate (from step (iv); 456 mg, 1.7 mmol) was dissolved in methanol (20 mL) and 10% palladium on carbon (50 mg) added. This suspension was hydrogenated at 20 psi hydrogen for 2 hrs then filtered. The filtrate was concentrated to give the title compound as a gum (214 mg, 1.66 mmol, 98% yield).

Provenance & Evidence