1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 86596031, compound

Participants

Reaction Steps

A solution of (R)-2-(1-(4-chlorophenylsulfonyl)-3-oxopiperazin-2-yl)acetic acid (1.98 g, 6.0 mmol), crude (R)-6-(2-(1,3-dithian-2-yl)ethyl)-1,2,3,4-tetrahydronaphthalen-1-amine (1.8 g, 6.45 mmol), HOBt (892 mg, 6.6 mmol) and EDCI(1.265 g, 6.6 mmol)in 15 mL of DMF was stirred overnight at room temperature. After quenching with Sat. NaHCO3 solution, the reaction mixture was extracted with EtOAc/hexane (1:1, 200 mL×2). The combined organic phase was washed brine, dried over Na2SO4, and evaporated in vaco. Flash chromatography (SiO2, hexane/EtOAc=2:1 to 3:2 to 1:1) gave the title compound as a white solid. MS: 609.7 (M+1).

Provenance & Evidence