HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-methyl-1H-indazol-5-amine → HCID 42613307, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-methyl-1H-indazol-5-amine | HCID 1382022 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 6-[4-(7-Methoxy-2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]pyrimidine-4-carboxylic acid | HCID 58386616 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 42613307 | HCID 42613307 | — |
Reaction Steps
100 mg (0.25 mmol) 6-[4-(7-methoxy-2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acid and 37 mg (0.25 mmol) 7-methyl-1H-indazol-5-amine in 74 μL (0.53 mmol) TEA and 1.5 mL DMF were combined with 89 mg (0.28 mmol) TBTU and stirred overnight at RT. Then the reaction mixture was purified by preparative HPLC-MS. The product-containing fractions were combined and freeze-dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08829006B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-bcca96945dbd43aabdfa1462f2b52063 |
| Source note | uspto-grants-2014_09 |