Ammonia → HCID 10074074, compound

Participants

Reaction Steps

To a solution of INTERMEDIATE 9 (100 mg, 0.21 mmol) in dichloromethane (3 mL) at −20° C. was added isobutyl chloroformate (41 μL, 0.31 mmol) and triethylamine (43 μL, 0.31 mmol). After 10 minutes a solution of ammonia in dichloromethane (1.5M, 4.5 mL, 3 mmol) was added. Reacton was warmed to room temperature and washed with brine. The organic layer was dried (MgSO4), filtered and concentrated to give COMPOUND 1.

Provenance & Evidence