7-Aminoquinoline → HCID 22135538, compound

HRID 747131Notes

Reaction equation

HRID 747131 reaction equation
[Cl:1][C:2]1[C:3]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)=[CH:4][C:5](F)=[N:6][CH:7]=1.[NH2:19][C:20]1[CH:29]=[C:28]2[C:23]([CH:24]=[CH:25][CH:26]=[N:27]2)=[CH:22][CH:21]=1>>[Cl:1][C:2]1[C:3]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)=[CH:4][C:5]([NH:19][C:20]2[CH:29]=[C:28]3[C:23]([CH:24]=[CH:25][CH:26]=[N:27]3)=[CH:22][CH:21]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 113777-AminoquinolineHCID 21865146HCID 21865146, compound

Product 1

HCID 22135538HCID 22135538, compound

Procedure

This compound could be prepared by the method described in Example 6(d) from 5-chloro-2-fluoro-4-(4-trifluoromethyl-phenyl)-pyridine and 7-aminoquinoline by microwave in a Smith Synthesizer (Personal Chemistry) at 180° C. for 20 min. The product will be isolated using flash chromatography.

Workup

  1. customThis compound could be prepared by the method
  2. customThe product will be isolated

Sources & evidence

ORD record
ord-3fd17ed18a7b4d8b9722a658642db6a9
Source dataset
uspto-grants-2008_07
Patent number
US07396831B2

Reaction notes

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