Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylate → 4-[6-(Quinolin-7-ylamino)-pyrimidin-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylate	HCID 4642098	—
Reactant	(6-Iodo-pyrimidin-4-yl)-quinolin-7-yl-amine	HCID 22135499	—
Product	4-[6-(Quinolin-7-ylamino)-pyrimidin-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester	HCID 23577236	—

Reaction Steps

This compound could be prepared from (6-iodo-pyrimidin-4-yl)-quinolin-7-yl-amine and 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester via Suzuki coupling reaction.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07396831B2
Source dataset	uspto-grants-2008_07
ORD ID	ord-30b7268f04524961bdb4d4f4b9a94a81
Source note	uspto-grants-2008_07