Hydrogen Bromide → HCID 59749166, compound

Participants

Reaction Steps

A solution of 6-(3-fluorophenyl)-5-(6-methoxy-3-pyridyl)-2,4-pyrimidinediamine (5.00 g, 16.1 mmol) in acetic acid (30 ml)/concentrated hydrobromic acid (50 ml) was stirred at 100° C. for 1.5 hours. After cooling as it was, the reaction mixture was adjusted to pH 12 to 13 with 5N sodium hydroxide and washed with ethylacetate. The aqueous layer was neutralized with 5N hydrochloric acid. The resulting solid was collected by filtration, to give the title compound (3.36 g, 70%) as a colorless solid.

Provenance & Evidence