反应详情

温度

70 °C

In an autoclave, 5-(2-fluoro-4-pyridyl)-4,6-di(2-furyl)-2-pyrimidinamine (200 mg, 0.621 mmol) was suspended in 1,2-dimethoxyethane (10 ml) and then a 50% dimethylamine aqueous solution (5 ml) was added thereto, followed by stirring at 70° C. After 11 hours, the reaction mixture was extracted with ethyl acetate, and the extract was washed with water and brine, dried over anhydrous sodium sulfate and then the filtrate was concentrated. The resulting solid was suspended in ethanol, collected by filtration and washed with ethanol, to give the title compound (92 mg, 43%) as a pale yellow solid.

1. extractionthe reaction mixture was extracted with ethyl acetate
2. washthe extract was washed with water and brine
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationthe filtrate was concentrated
5. filtrationcollected by filtration
6. washwashed with ethanol