Sodium Hydroxide → HCID 59749188, compound

Participants

Reaction Steps

In a reaction vessel, ethyl1-{4-[2-amino-4,6-di(2-furyl)-5-pyrimidinyl]-2-pyridyl}-4-piperidinecarboxylate (59 mg, 0.128 mmol) was suspended in methanol (0.8 ml). A 5N aqueous sodium hydroxide solution (0.2 ml) was added therto, followed by stirring at room temperature for 15 hours. After the reaction was terminated, the reaction mixture was extracted with ethyl acetate, washed with water and brine, dried over anhydrous sodium sulfate and then the filtrate was concentrated, to give the title compound (20 mg, 36%) as a white solid.

Provenance & Evidence