Ethyl Acetate → HCID 131726952, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 5-(2-fluoro-4-pyridyl)-4-(2-furyl)-2-pyrimidinylamine (300 mg, 1.17 mmol) and sodium cyanide in dimethylsulfoxide (3 ml) was stirred at 150° C. for 46 hours. After cooling as it was, the reaction mixture was diluted with ethyl acetate and washed with an aqueous solution of saturated ammonium chloride twice. The resulting organic layer was dried over anhydrous sodium sulfate and concentrated. The residue was subjected to silica gel plate (developing solvent; dichloromethane:methanol=10:1) and then washed with diethyl ether, to give the title compound (10 mg, 3%) as a colorless solid.

Provenance & Evidence