Allyl Alcohol → [3-(4-Bromophenyl)-4,5-dihydro-1,2-oxazol-5-yl]methanol

Participants

Role	Name	HCID	Charge
Reactant	Allyl Alcohol	HCID 7858	—
Reactant	4-Bromobenzaldehyde Oxime	HCID 608088	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	[3-(4-Bromophenyl)-4,5-dihydro-1,2-oxazol-5-yl]methanol	HCID 15888252	—

Reaction Conditions

Temperature	0 °C

Reaction Steps

4-Bromo-benzaldehyde oxime (162 g, 789.9 mmol) and allyl alcohol (130.5 ml) were added to tetrahydrofuran (1000 ml) and then bleach (5305 ml) was added. The reaction was cooled to 0° C. and stirred for 3 hrs. The precipitate was collected and washed with water (2×300 ml) to give the desired product (137 g).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07396847B2
Source dataset	uspto-grants-2008_07
ORD ID	ord-e016b6fdce5d44569339c050c2dfa5ea
Source note	uspto-grants-2008_07