Dichloromethane → HCID 5242140, compound

Participants

Reaction Conditions

Reaction Steps

[3-(4-Bromo-phenyl)-4,5-dihydro-isoxazol-5-yl]-methylamine (10 g, 39.1 mmol) and triethylamine (8.2 ml, 58.6 mmol) were added to anhydrous dichloromethane (100 ml) and cooled to 0° C. Acetyl chloride (3.0 ml, 43.6 mmol) was then added dropwise and the reaction was stirred for 3 hours followed by addition of ethyl acetate (200 ml). The precipitate was collected, washed with water (2×100 ml), and finally with ethyl ether (2×50 ml) to give the desired product (6.9 g).

Provenance & Evidence