Dichloromethane → HCID 59749456, compound

Participants

Reaction Conditions

Reaction Steps

[3-(4-Bromo-3-fluoro-phenyl)-4,5-dihydro-isoxazol-5-yl]-methylamine (9 g, 33.8 mmol) and triethylamine (7 ml, 50.8 mmol) were added to anhydrous dichloromethane (100 ml) and cooled to 0° C. Acetyl chloride (2.8 ml, 40.6 mmol) was then added dropwise and the reaction was stirred for 3 hours followed by addition of ethyl acetate (200 ml). The precipitate was collected and washed with water (2×50 ml) to give the desired product (5 g).

Provenance & Evidence