HCID 59749450, compound → HCID 59749489, compound

HRID 747230Notes

Reaction equation

[Si:1]([O:8][CH2:9][C@@H:10]1[O:14][C:13](=[O:15])[N:12]([C:16]2[CH:21]=[CH:20][C:19](I)=[CH:18][CH:17]=2)[CH2:11]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[F:23][C:24]1[CH:25]=[C:26]([N:34]2[CH2:38][C@H:37]([CH2:39][N:40]3[CH:44]=[C:43]([CH3:45])[N:42]=[N:41]3)[O:36][C:35]2=[O:46])[CH:27]=[CH:28][C:29]=1[Sn](C)(C)C>>[Si:1]([O:8][CH2:9][C@@H:10]1[O:14][C:13](=[O:15])[N:12]([C:16]2[CH:21]=[CH:20][C:19]([C:29]3[CH:28]=[CH:27][C:26]([N:34]4[CH2:38][C@H:37]([CH2:39][N:40]5[CH:44]=[C:43]([CH3:45])[N:42]=[N:41]5)[O:36][C:35]4=[O:46])=[CH:25][C:24]=3[F:23])=[CH:18][CH:17]=2)[CH2:11]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 59749450HCID 59749450, compound

HCID 59749514HCID 59749514, compound

Product 1

HCID 59749489HCID 59749489, compoundYield 4.3%

Procedure

Using essentially the same procedure as Example 28, but starting from (5R)-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-(4-iodophenyl)-1,3-oxazolidin-2-one (0.43 g, 1.00 mM) and adding (5R)-3-[3-fluoro-4-(trimethylstannyl)phenyl]-5-[(4-methyl-1H-1,2,3-triazol-1-yl)methyl]-1,3-oxazolidin-2-one (0.66 g, 1.50 mM) gave the title compound as a white solid (0.025 g).

Sources & evidence

ORD record: ord-c4e1738ed380401983936d9d4314487e
Source dataset: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07396847B2

Reaction notes

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