Sodium Hydroxide → HCID 178519869, compound

Participants

Reaction Steps

Quinolin-5-yl-(1-trityl-1H-imidazol-4-yl)-methanone (Intermediate G1) in acetic acid:water (˜2:1) was heated to 100° C. for 1 h. The mixture was basified with 1 M NaOH and extracted (6×) with CHCl3:iPrOH (3:1). The organic solution was dried over MgSO4, filtered, and concentrated onto silica gel. The material was eluted from a column of silica with 5% NH3-MeOH:CH2Cl2 to give (1H-imidazol-4-yl)-quinolin-5-yl-methanone (Intermediate G2).

Provenance & Evidence