反应详情

A mixture of 2-chloro-4-(4-chlorophenyl)-5-[3-(2-methoxyphenoxy)propyl]oxazole (378 mg), morpholine (435 mg) and 2-butanone (10 ml) was stirred with heating under reflux for 2 hours. The reaction mixture was poured into water (100 ml) and extracted with ethyl acetate (100 ml×2). The organic layer was washed with a 10% aqueous solution of citric acid (100 ml) and dried over anhydrous magnesium sulfate. After the organic layer was concentrated, the residue was recrystallized from ethyl acetate-hexane to give 4-(4-chlorophenyl)-2-(4-morpholinyl)-5-[3-(2-methoxyphenoxy)propyl]oxazole as pale yellow prisms (353 mg, 82%). Melting point 81-82° C.

1. temperaturewith heating
2. temperatureunder reflux for 2 hours
3. extractionextracted with ethyl acetate (100 ml×2)
4. washThe organic layer was washed with a 10% aqueous solution of citric acid (100 ml)
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationAfter the organic layer was concentrated
7. customthe residue was recrystallized from ethyl acetate-hexane