反应详情

To a mixture of 1-fluoronaphthalene (20.0 g) and adipic acid monoethyl ester chloride (27.5 g) was added gradually aluminum chloride (38.5 g) with stirring under ice-cooling, and the resulting mixture was stirred at room temperature for 2 hours. The reaction mixture was poured into ice water (500 ml) and extracted with diethyl ether (200 ml×2). The organic layer was washed with a 10% aqueous solution of sodium hydrogen carbonate (200 ml), dried over anhydrous magnesium sulfate, and concentrated to give ethyl 6-(4-fluoro-1-naphthyl)-6-oxohexanoate as an oil (27.7 g, 67%).

1. temperaturecooling
2. stirringthe resulting mixture was stirred at room temperature for 2 hours
3. extractionextracted with diethyl ether (200 ml×2)
4. washThe organic layer was washed with a 10% aqueous solution of sodium hydrogen carbonate (200 ml)
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated