Hydrochloric Acid → HCID 178486765, compound

Participants

Reaction Steps

A stirred solution of 23.57 g of ethyl 7-fluoro-4-hydroxy-6-methoxyquinoline-3-carboxylate in 71 cm3 of an aqueous 5N sodium hydroxide solution is brought to 100° C. for 3 hours. After cooling to ambient temperature, the reaction medium is acidified by adding 32.5 cm3 of an aqueous 37% hydrochloric acid solution. After addition of 150 cm3 of water, the precipitate obtained is filtered off and the solid is washed with water. After drying in the open air, 22 g of 7-fluoro-4-hydroxy-6-methoxyquinoline-3-carboxylic acid are obtained, in the form of a cream solid which melts at 275° C.

Provenance & Evidence