Cyclohexane → HCID 178469612, compound

Participants

Reaction Steps

A stirred solution of 37.75 g of diethyl 2-[(3-fluoro-4-methoxyphenylamino)methylene]malonate in 170 cm3 of diphenyl ether is brought to 245° C. for 3.5 hours. After cooling to ambient temperature, 220 cm3 of cyclohexane are added, and the precipitate thus obtained is filtered off and washed with cyclohexane and then with pentane and is spin-filtered to dryness. 24.10 g of ethyl 7-fluoro-4-hydroxy-6-methoxy-quinoline-3-carboxylate are obtained, in the form of a solid which melts at 280° C.

Provenance & Evidence