Citric Acid → HCID 22350968, compound

Participants

Reaction Steps

The compound (200 mg) obtained in the above (4) and triethylamine (100 mg) were dissolved in tetrahydrofuran (5 ml), and thereto was added p-toluenesulfonyl chloride (117 mg) at room temperature under nitrogen atmosphere. Two hours thereafter, to the reaction mixture was added a 10% aqueous citric acid solution, and the mixture was extracted with chloroform. The organic layer was washed with a saturated brine, dried over sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography [chloroform:methanol (97:32)] to give the title compound (240 mg) as amorphous.

Provenance & Evidence