4-Hydroxy-3-methoxybenzonitrile → HCID 58677394, compound

HRID 747548Notes

Reaction equation

HRID 747548 reaction equation
[CH:1]([C:3]1[S:7][C:6]([O:8][C:9]2[CH:17]=[CH:16][C:12]([C:13]([NH2:15])=O)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1)=[O:2].[OH:18][C:19]1C=CC(C#N)=CC=1OC>>[CH:1]([C:3]1[S:7][C:6]([O:8][C:9]2[CH:17]=[CH:16][C:12]([C:13]#[N:15])=[CH:11][C:10]=2[O:18][CH3:19])=[CH:5][CH:4]=1)=[O:2]

Participants

3

Reactant 2

HCID 781354-Hydroxy-3-methoxybenzonitrileHCID 58677395HCID 58677395, compound

Product 1

HCID 58677394HCID 58677394, compoundYield 17%

Procedure

Using a method similar to preparation of the compound of Example 1 part A, method A, and using 4-hydroxy-3-methoxy-benzonitrile (859 mg, 5.76 mmol) gives the title compound (225 mg, 17%). 1H NMR (Cl3CD): 9.71 (s, 1H), 7.54 (d, J=4.1 Hz, 1H), 7.30 (d, J=8.1 Hz, 1H), 7.28 (s, 1H), 7.23 (d, J=8.1 Hz, 1H), 6.53 (d, J=4.2 Hz, 1H), 3.89 (s, 3H).

Sources & evidence

ORD record
ord-1d4cdf924f394f85ab49f3a300861ef5
Source dataset
uspto-grants-2008_07
Patent number
US07396943B2

Reaction notes

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