反应详情

To 3.66 g of (2-amino-5-chlorophenyl)(3-methoxyphenyl)methanone dissolved in 15 ml of ethanol are added, at 20° C., 1.59 g of sodium borohydride. After 24 hours at 20° C., the reaction medium is concentrated, taken up in ethyl acetate and washed twice with water. The organic phase is dried over anhydrous sodium sulfate and concentrated. The residue is solidified with dichloromethane to give 2.37 g of the expected product.

1. additionare added, at 20° C.
2. concentrationthe reaction medium is concentrated
3. washwashed twice with water
4. dry with materialThe organic phase is dried over anhydrous sodium sulfate
5. concentrationconcentrated