Sodium Hydroxide → HCID 68569286, compound

HRID 747636Notes

Reaction equation

HRID 747636 reaction equation
[F:1][C:2]1[CH:36]=[CH:35][CH:34]=[C:33]([F:37])[C:3]=1[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[C:6]=1[N:13]([S:20]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH3:32])[CH:24]=1)(=[O:22])=[O:21])[CH2:14][C:15]([O:17]CC)=[O:16].[OH-].[Na+]>C(O)C>[F:1][C:2]1[CH:36]=[CH:35][CH:34]=[C:33]([F:37])[C:3]=1[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[C:6]=1[N:13]([S:20]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH3:32])[CH:24]=1)(=[O:22])=[O:21])[CH2:14][C:15]([OH:17])=[O:16]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68566353HCID 68566353, compound

Product 1

HCID 68569286HCID 68569286, compoundYield 105.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 1.8 g of ethyl N-[2-(2,6-difluorobenzyl)-6-methoxyphenyl]-N-[(3,4-dimethoxyphenyl)sulfonyl]-glycinate dissolved in 50 ml of ethanol are added 10 ml of 2M sodium hydroxide solution. After 18 hours at room temperature, the medium is extracted with diethyl ether and the aqueous phase is acidified and extracted with dichloromethane. The organic phase is dried over anhydrous sodium sulfate and then concentrated to give 1.8 g of the expected product.

Workup

  1. extractionthe medium is extracted with diethyl ether
  2. extractionextracted with dichloromethane
  3. dry with materialThe organic phase is dried over anhydrous sodium sulfate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-c7f29ed9305247bb92219dc68f425d0a
Source dataset
uspto-grants-2008_07
Patent number
US07396958B2

Reaction notes

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