HCID 55285521, compound → HCID 59749717, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 3-amino-5-(4-fluorophenyl)-2-pentenoate 4 (119 mg, 0.5 mmol), 4-formyl-N-pyridin-3-ylmethyl-benzamide 8 (120 mg, 0.5 mmol) and 3-Imino-5-methyl-hexanoic acid amide 11 (92 mg, 0.65 mmol) were dissolved in EtOH (4 mL). The reaction was stirred at 120° C. overnight. The crude reaction mixture was purified via reverse phase LC/MS to yield, 29 mg of target material. The compound was characterized by NMR and LC/MS. 1H NMR (500 MHz, CDCl3): δ 8.79 (s, 1H), 8.51 (d, J=4.7 Hz, 1H), 8.29 (d, J=7.9 Hz, 1H), 7.68 (m, 4H), 7.28 (d, J=8.5 Hz, 1H), 7.08 (m, 2H), 6.90 (m, 2H), 4.63 (br. s, 2H), 4.04 (q, J=6.8 Hz, 2H), 3.37 (s, 1H), 2.86 (q, J=7.2 Hz, 2H), 2.78 (m, 3H), 2.50 (m, 1H), 1.65 (m, 1H), 1.17 (t, J=6.7 Hz, 3H), 0.82 (t, J=6.9 Hz, 6H).

Provenance & Evidence