反应详情

8 g of benzyl-N-(2-bromoethyl)carbamate, 3.7 g of 3-hydroxybenzonitrile, 4.3 g of calcium carbonate, 5.1 g of potassium iodide and 1.1 g of tetrabutylammonium iodide were stirred in dimethylformamide at 60° C. After the treatment with ethyl acetate as the extractant in an ordinary manner, the product was purified by the silica gel column chromatography to obtain 3-[2-(benzyloxycarbonylamino)ethoxy]benzonitrile. Acetic acid containing 20% of hydrogen bromide was added to the product under cooling with ice, and the resultant mixture was stirred at room temperature for 2 hours. The solvent was evaporated, and the residue was washed with ethyl acetate to obtain the title compound.

1. customAfter the treatment with ethyl acetate as the extractant in an ordinary manner, the product was purified by the silica gel column chromatography