反应详情

100 mg (0.31 mmol) of methyl 4-[N-[2-(3-cyanophenoxy)ethyl)carbamoyl]benzoate was stirred in 100 ml of 28% aqueous ammonia overnight. The reaction liquid was evaporated under reduced pressure, and 1 N hydrochloric acid was added to the residue. After the extraction with ethyl acetate, the organic layer was washed with saturated aqueous NaCl solution and then dried over anhydrous magnesium sulfate. The solvent was evaporated to obtain the title compound.

1. customThe reaction liquid
2. customwas evaporated under reduced pressure, and 1 N hydrochloric acid
3. additionwas added to the residue
4. extractionAfter the extraction with ethyl acetate
5. washthe organic layer was washed with saturated aqueous NaCl solution
6. dry with materialdried over anhydrous magnesium sulfate
7. customThe solvent was evaporated