HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Ethyl 1-(pyridin-4-yl)piperidine-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| Reactant | 4-Chloropyridine hydrochloride | HCID 81852 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | Ethyl 1-(pyridin-4-yl)piperidine-4-carboxylate | HCID 9899468 | — |
Reaction Steps
4.0 g (26.6 mmol) of 4-chloropyridine hydrochloride, 4.2 g (26.6 mmol) of ethyl piperidine-4-carboxylate and 7.4 ml (53.2 mmol) of triethylamine were stirred in 100 ml of xylene at 130° C. for 24 hours. After the treatment with ethyl acetate as the extractant in an ordinary manner, the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07396844B1 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-2f469e104ccf4bfd97ef04ffefb8edc1 |
| Source note | uspto-grants-2008_07 |