Dimethylformamide → HCID 68829666, compound

Participants

Reaction Conditions

Reaction Steps

6.4 g (12.7 mmol) of benzyl 3-[4-[(2S)-3-chloro-2-(t-butoxycarbonylamino)propyl]phenoxy]piperidine-1-carboxylate was dissolved in 70 ml of dimethylformamide. 2.27 g (19.1 mmol) of 3-cyanophenol and 3.51 g (25.4 mmol) of potassium carbonate were added to the solution, and they were stirred at 70° C. for 15 hours. After the treatment with ethyl acetate as the extractant in an ordinary manner, the crude product was obtained, which was purified by the silica gel column chromatography to obtain the title compound.

Provenance & Evidence