Triethylamine → HCID 57206721, compound

Participants

Reaction Steps

1.12 g (2.73 mmol) of benzyl (2S)-2-t-butoxycarbonylamino-4-(3-cyanophenoxy)butanoate was dissolved in 10 ml of 4 N solution of hydrogen chloride in dioxane, and they were stirred at room temperature for 2 hours. The solvent was evaporated, and the obtained oily residue was dissolved in 14 ml of dichloromethane. 390 mg (2.73 mmol) of 4-cyanobenzoic acid, 405 mg (3.00 mmol) of HOBt, 0.83 ml (6.00 mmol) of triethylamine and 575 mg (3.00 mmol) of WSC.HCl were successively added to the solution under cooling with ice, and they were stirred at room temperature overnight. After the treatment with methylene chloride as the extractant in an ordinary manner, the title compound was obtained.

Provenance & Evidence