Sodium Hydroxide → 1-(1,1-Dimethylethyl) (3S)-3-[4-(carboxymethyl)phenoxy]-1-pyrrolidinecarboxylate

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Reaction Steps

750 mg of ethyl 2-[4-[(3S)-1-(t-butoxycarbonyl)-3-pyrrolidyloxy]phenyl]acetate was dissolved in 10 ml of ethanol. 4 ml of 1 N aqueous sodium hydroxide solution was added to the obtained solution. After stirring at room temperature overnight, the solvent was evaporated. 1 N hydrochloric acid was added to the residue. After the same isolation process as that of step 1 in Example 1 with ethyl acetate as the extractant, the title compound was obtained.

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