Triethylamine → Benzyl 4-Hydroxy-1-piperidinecarboxylate

Participants

Reaction Steps

25.0 g (247 mmol) of 4-hydroxypiperidine was dissolved in 800 ml of dichloromethane. 38 ml (266 mmol) of benzyl chloroformate and 75 ml (538 mmol) of triethylamine were added to the solution at 0° C., and they were stirred at room temperature for 15 hours. After the treatment with dichloromethane as the extractant in an ordinary manner, an oily residue was obtained. This residue was subjected to the subsequent reaction without further purification.

Provenance & Evidence