Ethyl 2-benzyl-8-hydroxy-1-oxo-3,4-dihydropyrrolo[1,2-a]pyrazine-7-carboxylate → 2-[(4-Fluorophenyl)methyl]-8-hydroxy-1-oxo-3,4-dihydropyrrolo[1,2-a]pyrazine-7-carboxylic acid

HRID 747844Notes

Reaction equation

HRID 747844 reaction equation
C(N1CCN2C=C(C(OCC)=O)C(O)=C2C1=O)C1C=CC=CC=1.[F:24][C:25]1[CH:47]=[CH:46][C:28]([CH2:29][N:30]2[CH2:35][CH2:34][N:33]3[CH:36]=[C:37]([C:40]([O:42]CC)=[O:41])[C:38]([OH:39])=[C:32]3[C:31]2=[O:45])=[CH:27][CH:26]=1>>[F:24][C:25]1[CH:26]=[CH:27][C:28]([CH2:29][N:30]2[CH2:35][CH2:34][N:33]3[CH:36]=[C:37]([C:40]([OH:42])=[O:41])[C:38]([OH:39])=[C:32]3[C:31]2=[O:45])=[CH:46][CH:47]=1

Participants

3

Reactant 2

HCID 3011066Ethyl 2-benzyl-8-hydroxy-1-oxo-3,4-dihydropyrrolo[1,2-a]pyrazine-7-carboxylateHCID 3011068Ethyl 2-[(4-fluorophenyl)methyl]-8-hydroxy-1-oxo-3,4-dihydropyrrolo[1,2-a]pyrazine-7-carboxylate

Product 1

HCID 30110692-[(4-Fluorophenyl)methyl]-8-hydroxy-1-oxo-3,4-dihydropyrrolo[1,2-a]pyrazine-7-carboxylic acid

Procedure

The title compound was prepared using a procedure similar to that described in Example 2, except that ethyl 2-benzyl-8-hydroxy-1-oxo-1,2,3,4-tetrahydropyrrolo-[1,2-α]pyrazine-7-carboxylate was substituted wit ethyl 2-(4-fluorobenzyl)-8-hydroxy-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-α]pyrazine-7-carboxylate.

Sources & evidence

ORD record
ord-1b92f05d3a6842a891db6632a0c9741c
Source dataset
uspto-grants-2008_07
Patent number
US07399763B2

Reaction notes

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