Ethyl 2-benzyl-8-hydroxy-1-oxo-3,4-dihydropyrrolo[1,2-a]pyrazine-7-carboxylate → 2-[(3-Chlorophenyl)methyl]-8-hydroxy-1-oxo-3,4-dihydropyrrolo[1,2-a]pyrazine-7-carboxylic acid
Reaction equation
C(N1CCN2C=C(C(OCC)=O)C(O)=C2C1=O)C1C=CC=CC=1.[Cl:24][C:25]1[CH:26]=[C:27]([CH:45]=[CH:46][CH:47]=1)[CH2:28][N:29]1[CH2:34][CH2:33][N:32]2[CH:35]=[C:36]([C:39]([O:41]CC)=[O:40])[C:37]([OH:38])=[C:31]2[C:30]1=[O:44]>>[Cl:24][C:25]1[CH:26]=[C:27]([CH:45]=[CH:46][CH:47]=1)[CH2:28][N:29]1[CH2:34][CH2:33][N:32]2[CH:35]=[C:36]([C:39]([OH:41])=[O:40])[C:37]([OH:38])=[C:31]2[C:30]1=[O:44]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared using a procedure similar to that described in Example 2, except that ethyl 2-benzyl-8-hydroxy-1-oxo-1,2,3,4-tetrahydropyrrolo-[1,2-α]pyrazine-7-carboxylate was substituted with ethyl 2-(3-chlorobenzyl)-8-hydroxy-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-α]pyrazine-7-carboxylate.
Sources & evidence
- ORD record
- ord-4a55d742f70f4bf482e7432e19857b3c
- Source dataset
- uspto-grants-2008_07
- Patent number
- US07399763B2
Reaction notes
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