2-(Tributylstannyl)furan → HCID 178441006, compound

Participants

Reaction Conditions

Reaction Steps

1-(4-tert-Butyl-anilino)4[5-(furan-2-yl)-6-methoxy-(pyridin-3-yl)-methyl]phthalazine: To a solution of 366 mg (0.76 mMol) 1-(4-tert-butyl-anilino)-4-[5-bromo-6-methoxy-(pyridin-3-yl)-methyl]phthalazine (Ex. 17: a) In 7 ml degassed DMF under a N2-atmoshere are added 174 mg (0.15 mMol) of Pd[P(C8H5)3]4 and 0.6 ml (1.9 mMol) of 2-tributylstannyl-furan (Aldrich). After 4 h stirring at 100° C., the reaction mixture is diluted with EtOAc and washed with NaHCO3 solution. The aqueous layers are extracted twice with EtOAc, the organic phases washed with water, brine, dried (Na2SO4) and concentrated in vacuuo. Column chromatography (SiO2; CH2Cl2/Et2O 7:3) and cristalization from DIPE yields the title compound. mp: 180-182° C.; ES-MS: (M+H)+=465; HPLC(Grad20-100) tRet=15.0.

Provenance & Evidence